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This is the most significant limitation No statistical significance testing: The paper does not report p-values or statistical tests

195,214 AXIN mutations are present in ~10% of hepatocellular carcinomas (HCCs)

However, on the TNF flow cell surface, all dosed subjects in cohort 7 showed increasing signal compared to baseline which was confirmed with the anti-human IgG reagent, but not the AMG 966-specific antibody 1A3, indicating these subjects developed endogenous anti-TNF antibodies as a result of AMG 966 treatment ( Figures 8F, H )

However, the in vitro co-culture assay did not detect a reduction in the number of neural progenitors (Fig