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Documented Long-Term Side Effects of NSAIDs Regular or long-term NSAID use has been associated with: Damage to the gut lining, increasing intestinal permeability (leaky gut) and immune activation (27,29,31) Reduced absorption of key nutrients, including iron, folate, and vitamin C (28,29) Delayed tissue repair , particularly in connective tissue where prostaglandins are required for healing (32) Kidney stress and electrolyte imbalance , especially during dehydration or endurance activity (30) Increased cardiovascular risk , particularly with higher doses or prolonged exposure (30) These effects help explain why NSAIDs may temporarily reduce pain while progressively impairing healing capacity, increasing systemic inflammation, and slowing long-term recovery

3.1.6 Other interventions Other types of interventions can be used to modulate the gut microbiota, such as diets (e.g., Mediterranean diet), fecal matter transplant, and antibiotics (57, 89, 90)

It is an essential process in maintenance of the health of mitochondria

Another study found that the number of CD4 + T RM cells in DSS-induced colitis mice was significantly higher than that in normal mice, and the number of CD4 + CD69 + CD103 - T RM cells was positively correlated with the disease activity index (48)