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Avoid concomitant administration of ibuprofen for 2 days before, the day of, and 2 days following administration of Pemetrexed Injection [see Warnings and Precautions (5.6) and Drug Interactions (7)]

Experts from IOIBD and GIVES-21 confirmed the inclusion of studies, verified data accuracy and suggested additional studies that may have been missed (Supplementary Fig