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And there are a lot of that I've seen clinically that have irr, not even irritable Crohn's colitis and they're suffering

Topical NSAIDs (such as ibuprofen gel) offer localised pain relief with minimal systemic absorption and are recommended by NICE as first-line for localised joint pain

Thats why the most effective approach isnt just picking the right GLP-1

Transected rat Achilles tendons treated with BPC-157 showed accelerated recovery with improved load-bearing capacity, superior functional scores, and better collagen fiber organization compared to controls