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Mechanistically, B12 deficiency leads to elevated homocysteine levels and impaired methylation pathways, contributing to neuronal toxicity and cerebrovascular damage

Cited 14 Sept 2015]

The synthetic NBD peptide, which mimics the S100A4-binding domain of MetAP2, has been demonstrated to regulate the expression of genes related to angiogenesis and suppress capillary formation in murine endothelial cells (Takenaga et al., 2021)