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167 Evasion of apoptosis brought about by H 2 S has been attributed mostly to CSE-generated H 2 S mediating the per-sulphidation of key proteins in different signalling pathways: nuclear factor-B (NF-B) in hepatoma cells, 168 the Keap1-transcriptional regulator of NRF2, 169 and the extracellular-signal-regulated kinase (ERK)-activating protein kinase 1

The rapid onset of diuretic action indicates quick absorption from the intestine, and the ethanolic fraction has a long-lasting effect, particularly at higher doses, which is beneficial for reducing the frequency of administration of loop diuretics (46, 476)

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