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A better understanding of the multiple molecular mechanisms involved in the cellular action of fumaric acid esters (FAEs) will help to adapt and to further improve the use of such small molecules for the treatment of psoriasis and other chronic inflammatory diseases (6)

On the first day, bilateral vertebral arteries were irreversibly electro-cauterized under anaesthesia with sevoflurane (a mixture of 3.5% sevoflurane in 33% O 2 and 66% N 2 O)

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A total number of 2635 raw movie stacks made of 50 frames each were collected with SerialEM 87 from a single individual session with a GLACIOS 200 kV FEG Cryo-TEM (ThermoFisher Scientific) using a K2 Summit detector (Gatan Inc., USA) at 36000 magnification and pixel size of 1.145 /pixel without pre-exposure and using a defocus of 2.6 to 1.8 m and 50 e - / 2 total dose per stack (1 e - / 2 per frame)