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doi:10.1039/d1fo02239c 257

The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository (proteomexchange.org) with the data set identifier PXD036803 ( The mass spectrometry metabolomics data (2 data sets from kidney and plasma, respectively) have been deposited to the Zenodo repository ( All reagents, softwares, mouse lines, and data repository information are available in Supplemental Table 7

A hallmark of the ligand interactions it that both bind FcRn in a strictly pH-dependent manner, with binding at mildly acidic pH (pH 6.55.0) and no binding or release at pH 7.4 [23, 28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]