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Beyond these neuroendocrine factors, the concentrations of macro and micronutrients and immunological components have also been shown to exhibit diurnal fluctuations

Stull, J

ISSN 0007-4888

The presence of these cells in tissues disrupts the normal tissue architecture and impairs regenerative capacities, leading to functional decline.2 For example, in skeletal muscle, the accumulation of senescent cells has been linked to sarcopenia, the age-related loss of muscle mass and function.24 Chronic Diseases: The inflammatory environment created by senescent cells contributes to the pathogenesis of several chronic diseases