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Neurology 68 , S22S31 (2007)

This review draws upon the literature from the past decade to systematically analyze how ammonia metabolic reprogramming shapes an immune-suppressive, metabolism-supportive tumor microenvironment landscape, thereby promoting tumor initiation and progression

These changes reduce its binding affinity to IGF-binding proteins (IGFBPs), allowing for a longer half-life (up to 2030 hours) and increased bioavailability in plasma