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These results, which suggest that D-Nle- Tyr-Ile-NH-(CH 2 )5-CONH 2 is likely to be relatively hydrophobic, are in agreement with the outcome of QSAR modeling estimates generated by ADMET Predictor that calculated an octano water partition coefficient of 28.18 for D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 (Table 6)

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Mayo Clinic Proceedings 90(9): 12331246 [PubMed] [PMC] Street ME, Angelini S, Bernasconi S, Burgio E, Cassio A, Catellani C, Cirillo F, Deodati A, Fabbrizi E, Fanos V, Gargano G, Grossi E, Iughetti L, Lazzeroni P, Mantovani A, Migliore L, Palanza P, Panzica G, Papini AM, Parmigiani S, Predieri B, Sartori C, Tridenti G, Amarri S (2018) Current knowledge on endocrine disrupting chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood: highlights from a National Italian Meeting

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