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CDP promoted melanogenesis by activating MAPK signaling pathway and up regulating the expression of MITF and its downstream genes Tyr, TRP1 and Trp2, including increasing the phosphorylation levels of p38, JNK and ERK proteins

Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)