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The temporal pattern matters too

Gene silencing Gene silencing techniques, including RNAi and antisense oligonucleotides, are used to reduce the expression of toxic or overactive genes (Rinaldi and Wood, 2018)

A randomized, controlled, open-label, crossover phase 2 study of 1 month of A-dopamine versus 1 month of optimized oral antiparkinsonian therapy was conducted in 9 patients