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Although a detailed characterization of muscle phenotypes has yet to be performed, osteoprogenitor igf-1r ( Osterix-Cre igf-1r ) and Cart igf-1r conditional knockouts, display proportionately smaller muscles concomitant with a shorter and smaller skeleton (unpublished qualitative observations)

This works for motivated patients tolerating mild transient side effects but risks premature discontinuation if effects become overwhelming