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By contrast, serine itself is an allosteric inhibitor of PHGDH, and this allosteric inhibition can spontaneously disappear at low serine levels (Sugimoto and Pizer, 1968)

Figure 2 3.1 Activation of the Nrf2/ARE pathway The Nrf2/ARE pathway exerts cross-regulatory control over neuroinflammation and mitochondrial function through multiple mechanisms (84)