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In a 1992 study in rats, the major finding was that intraperitoneal DSIP injection increased the concentration of substance P a neurotransmitter positively correlated with the regulation of anxiety and mood15 in the hypothalamus, suggesting to the researchers that the peptide sharply decreases the classical manifestations of stress.16 Earlier studies in humans, namely a series of five trials published in 1983, came to similar conclusions, with better relaxation and apparently improved tolerance against psychic stress reported by the subjects.17 Its possible that the improved stress and anxiety markers were consequent to DSIP-associated sleep enhancements.18 Substance use recovery A study from 1984 published in European Neurology describes DSIPs potential use as a treatment for alcohol and opiate use disorders

GHK-Cu plays a regulatory role in many processes related to tissue remodeling, immune response, and inflammation control

In Duchenne muscular dystrophy (DMD) patients, He-Ne laser irradiation has been shown to alleviate oxidative stress by increasing nitric oxide (NO) levels and reducing lipid peroxidation, thereby slowing disease progression (103)

Notably, 64 integrin can promote resistance to ferroptosis (section 2.3