mucosal melanotic lesions Labial Lentigo (labial macule) Focal melanocytic lesions of the

39 , e90e96 (2011)

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These combined actions highlight their therapeutic potential in preventing and treating chronic diseases characterized by oxidative stress and inflammation

[2] Symptoms in dogs include: [8] Urinary incontinence Polydipsia Polyphagia An enlarged stomach or 'potbelly' Lethargy Skin disease Muscle wasting Dermatological symptoms include: [2] Haematoma Alopecia Chronic skin infections Self-mutilation Seborrhoea Pyoderma Calcinosis cutis Hyperpigmentation Comedones Rare clinical signs of Cushings include: [2] Thromboembolism Congestive heart failure Bronchial calcification Blindness Polyneuropathies Enlarged prostate Testicular atrophy Retarded muscle relaxation Behavioural changes (if the tumour is large enough) A potbelly appearance is present in 90% of dogs with Cushing's, the cause is a hormonal redistribution of body fat and the breakdown of abdominal muscles