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Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration-resistant prostate cancer

Moreover, The depletion of Phosphoseryl-tRNA kinase (PSTK) results in the inactivation of GPX4 and the disruption of GSH metabolism ( in vitro and in vivo ( c /GSH/GPX4 axis in combination with chemotherapeutic agents (e.g., sorafenib) provides new ideas for treatment of drug-resistant HCC

M.CarrilhoE.et al

Electrophysiology results from hippocampal sections showed that xCT-deficient mice have a prolonged latency of hypoxia depolarization after complete hypoxia compared with wild-type mice