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Recombinant methioninase effectively targets a Ewings sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model

Interestingly, we have reported that intranuclear localization of AIF involves in the peroxynitrite-induced apoptosis of SGNs (Liu et al., 2012), whether GPX1 regulates the intranuclear localization of mitochondrial AIF to alleviate apoptosis in SGNs after peroxynitrite injury deserved further exploration