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Early studies performed in the 1960s injected monomer and higher order molecular weight protein particulates of bovine gamma globulin into rodents

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Although useful for studies of protein-mediated transport, for helping describe the contributions of specific proteins toward transcellular and paracellular solute and ion transport, and for high-throughput drug screening, [77, 78] extrapolation of data supporting the transport of microorganisms or large lipophilic molecules from cultured cells to the intact epithelium is at best hazardous

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