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Loss- and gain-of-function experiments in mice demonstrate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose tolerance and insulin sensitivity

This impairment of homeostasis initiates pathological changes, including mitochondrial dysfunction, lipid peroxidation, immune suppression, and the activation of proinflammatory pathways (Dey et al., 2024)

10.1084/jem.20130315 J

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