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In rat models of PD, IN DFO has been reported to protect dopaminergic neurons in the substantia nigra and ameliorate motor deficits, suggesting IN DFO reaches the midbrain regions at pharmacologically active concentrations (Febbraro et al., 2013)

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Research using Morris water maze (spatial memory), passive and active avoidance (fear-motivated learning), novel object recognition, and operant conditioning tasks shows that Semax improves acquisition, consolidation, and retrieval of memory in both normal animals and those with experimentally induced cognitive impairment

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