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Studies in individuals with dementia and other related pathologies are not covered in this article

Clinicians initiate lofexidine at 0.53 mg three times daily and increase the dose to 2.88 mg daily as needed (92)

The most common normal localized reactions include: Redness (erythema) at the site Swelling or a small raised bump Tenderness or slight pain Mild warmth Itching Small bruising These reactions are typically: Localized to a small area (12 inches in diameter) Mild to moderate in intensity Resolve within 2448 hours Not progressively worsening Many patients will experience some degree of redness or swelling during the first week or two of therapy as the immune system acclimates

Those with chronic health conditions or using multiple medications should discuss with a healthcare provider before use