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Vegetarians or vegans If your diet doesnt consist of the proper amounts of meat, fish and eggs Over age 50 Pregnant or breastfeeding Cigarette smokers If you take medications for heartburn or take potassium supplements If youve had part of your stomach surgically removed or banded / VITAMIN B12 DEFICIENCY AND CHRONIC FATIGUE SYNDROME Why is a lack of B12 of such concern

Primary research: Type 2 diabetes, obesity, metabolic disease Mechanism: Dual activation of GIP and GLP-1 receptors for enhanced metabolic effects Regulatory status: FDA-approved (Mounjaro 2022, Zepbound 2023) Key data: Up to 22.5% weight loss in SURMOUNT trials

6 Persistence Data Patients who start KESIMPTA, stay on KESIMPTA Persistence and adherence with KESIMPTA and other first-line options 13-15 Persistence was defined as the time in months from the index date until treatment discontinuation