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This is the case because folate is needed as the coenzyme 5,10-methylene-THF polyglutamate for conversion of dUMP to dTMP

It is also of clinical benefit to some patients with -thalassemia intermedia and it reduces the need for transfusions in a subset of individuals with -thalassemia major [46], [47], [48], [49], [50], [51], [52], [53]