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Liver fibrosis was mitigated when ferroptosis was simultaneously inhibited by global knockout or inhibition of COX-2, supporting the notion that ferroptosis of hepatocytes is detrimental to the progression of chronic liver disease

The PLB-985 neutrophils were not treated with NAC, but we included in this assay the gp91 phox KO-PLB-985 cells (hereafter referred to as PLB-985- nox2 KO) [22]

In biological systems, hydroxyl radicals can be formed by homolytic cleavage of water using high-energy irradiation or more probably, by redox metal-catalyzed decomposition of hydrogen peroxide (reaction 7, Fenton reaction)

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