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Altered glutamate, glutamine, arginine, tryptophan, BCAA, and homocysteine metabolism have been found to have a greater impact on DR as depicted in Figure 4 (Ola et al., 2013, 2019)

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These undesired unspecific effects are frequently mediated by the carrier molecules, which deliver their payload not only to the addressed tumor site but also to healthy tissues, which express the targeted markers as well