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The overall concordance in the equivalent risk-level classification provided by the three DDI databases was evaluated using the Fleiss kappa and Gwets AC1 coefficient, while Cohens kappa coefficient was used to determine the pairwise classification concordance among two lists

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The 12mg dose, which produces 24-29% weight loss, carries theoretically higher risk than the 1mg dose at 8.7% weight loss

[81] This complex is much more lipophilic than the water-soluble vitamin B 12 , so is able to pass through cellular membranes with greater ease