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If concomitant ibuprofen use cannot be avoided, monitor patients more frequently for pemetrexed adverse reactions, including myelosuppression, renal, and gastrointestinal toxicity [see Dosage and Administration (2.5), Drug Interactions (7), and Clinical Pharmacology (12.3)]

As federal oversight increases and budget pressure intensifies, hospitals and health systems must proactively align their programs with CMS expectations to safeguard future funding.

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