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BV-2 cells were seeded in 24-well plates overnight at a density of 2 10 5 cells/well

Matschke et al., 2016), with a naturally high resistance to treatment due to an augmentation in hypoxia-inducible factor-1 alpha (HIF-1) (Hsieh et al., + increases with distance from the blood vessels due to the distance of diffusion and the increased production of lactate from anaerobic cells, creating a highly acidic region (Fang et al., 2000