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The maximum STS dose group of STS 9 mg/24 hours and STS 12 mg/24 hours included more elderly patients because the open-label flexible-dose study had no upper age limit and because the dose was titrated up to the maximum dose tolerated in the trial

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Patients with a history of gastroparesis, irritable bowel syndrome, or frequent acid reflux should discuss this in detail, as semaglutides gastric-slowing effects can interact with these conditions

Early treatment matters because a small issue can slowly turn into a much bigger daily problem