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This upregulation exhausts intracellular GSH, leading to ROS buildup and oxidative DNA damage that can ultimately generate TP53 mutations, a process that is halted when CHAC1 is knocked down (Wada et al., 2018)

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3 The promise of RCD in targeted glioma therapy 3.1 Potential application of autophagy-dependent cell death in glioma targeted therapy Autophagy-dependent cell death is a type of RCD that relies on autophagy mechanisms or components and plays a significant role in the central nervous system ( The underlying mechanisms of autophagy that contribute to cellular death are notably distinct from those that promote cellular survival