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As revealed by recent investigation (124), MSCs could promote the growth of tumor blood vessels and recruit immunosuppressive myeloid cells by interacting directly with tumor cells and interacting with other components of the tumor microenvironment, thereby driving tumor immune rejection aas well as playing a key role in tumor progression and metastasis

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49,51,52 In addition, imbalanced glutamate and GABA activity may contribute to a link between depression and chronic pain