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It is made of the first 29 amino acids of the native hormone, which appears sufficient for activating the GHRH receptors in the somatotroph cells in the anterior pituitary gland and triggering growth hormone release

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In consideration of the multiple metabolic and cardiovascular effects seen in subjects treated with GLP-1RAs and SGLT-2is (e.g., reduction of hyperglycemia, weight loss, free/fat mass and bone remodeling, anti-atherosclerosis, natriuresis), it is reasonable to speculate that GH and IGF-1 may play a about a relevant role in this context