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Chung et al., 2021)

ICI monotherapy versus combined ICI is associated with fewer irAEs

Itaconate promotes tumor growth via oxidative phosphorylation-driven ROS generation in peritoneal tissue-resident macrophages and concomitant ROS-mediated mitogen-activated protein kinases (MAPKs) activation in tumor cells (79)

By using ferroptosis inducers, it is possible to enhance iron accumulation and ROS levels in GC cells, thereby triggering ferroptosis and suppressing cell proliferation (71)