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Another recent published work demonstrated that reduced NRF2 expression is responsible for the decline of neural stem/progenitor cell (NSPC) function, as it is found that NRF2 expression was suppressed in the aged NSPC, and overexpression of NRF2 in those old cells could render them to a similar state as the young NSPCs, by showing increasing cell survival and regeneration [126]

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Both alternatives are effective when doxycycline is not appropriate

Finally, several members of a bacterial SdiE effector family from Legionella pneumophila function as an E3 ligase and catalyze NAD-dependent ubiquitination on serine of multiple host GTPases, which is independent of ATP, E1, and E2 enzymes (Qiu et al