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Separately, misfolded or aggregated proteins in the cytosol participate in stress granule formation

35,36 Observed elevations in homocysteine in 3R3R individuals imply the methylation pathway is being hindered in favour of de novo thymidylate synthesis

43,44 In 1984, Krieg and Melton used RNA polymerase extracted from viruses for in vitro transcription from engineered DNA templates, successfully achieving mRNA expression in cell-free systems