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Medical literature suggests a strong biologic plausibility between opioid analgesics and OIH and allodynia

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Plant Cell Physiol 34:881889 Miyake C, Michihata F, Asada K (1991) Scavenging of hydrogen peroxide in prokaryotic and eukaryotic algae: acquisition of ascorbate peroxidase during the evolution of cyanobacteria

The following aspects will be discussed in the next paragraphs (i.e., stone composition, location, pathogenesis, and clinical manifestation)