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Furthermore, through fusion gene design, target proteins (such as targeting peptides) can be enriched on the EV membrane surface, effectively enhancing their tissue targeting

The ubiquitinated proteins are recognized by the sorting machinery of early endosomes, which does not gather these integral proteins for being included in vesicles shipped to plasma membrane

This result highlighted the importance of the synergistic/additive properties of the two synthetic moieties on dual-modified protein bioconjugates and provides avenues to expand its applications in introducing FRET donor-acceptor dyes for analysis of protein structures, protein-protein interactions and combining drug molecules with imaging agents to design precision protein therapeutics 43,44,45

Available at Last reviewed 02/13/24