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reported that increased ROS levels stemming from ER stress and mitochondrial dysfunction contribute to A53T -syn-induced cell death (Smith et al., 2005)

Lountos GT, Tropea JE, Waugh DS

High levels of cysteine are toxic in some systems, in part because its amino, carboxyl, and thiol groups are well situated stereochemically to chelate metal ions, which catalyze air oxidation of its thiol group

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