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Commonly used scales, such as the NIH Stroke Scale or Glasgow Coma Scale, are calibrated for acute neurological deficits but are poorly suited to detecting the gradual, molecular-level improvements that characterize many neuroprotective strategies

Patients with bipolar disorder appear to have a higher number of noradrenergic neurons in the locus ceruleus as well as subtle structural deficits of serotonergic neurons in the dorsal raphe (164)

Together, they decrease levels of TNF-, IL-6, and CRP, preventing chronic inflammation and promoting a stable biochemical environment for regeneration and repair