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Limited access to laboratory tests, imaging technology, and pathology services further hampers the ability to monitor disease activity and adjust treatment plans accordingly

Glossary T2DM type 2 diabetes mellitus AMPK AMP-activated protein kinase LKB1 liver kinase B1 ETC electron transport chain mTOR mammalian of mechanistic target of rapamycin TFEB Transcription Factor EB eNOS endothelial nitric oxide synthase PEN2 presenilin enhancer 2 mGPD2 mitochondrial glycerol-3-phosphate dehydrogenase G3P glycerol-3-phosphate DHAP dihydroxyacetone phosphate ULK unc-51 like autophagy activating kinase LV left ventricle LVEF Left Ventricular Ejection Fraction CAD coronary artery disease AMI acute myocardial infarction STEMI ST-Elevation Myocardial Infarction I/R ischemia-reperfusion NLRP3 NLR Family Pyrin Domain Containing 3 ROS reactive oxygen species mPTP mitochondrial permeability transition pore LPS Lipopolysaccharide MMP matrix metalloproteinase TIMP-1 Tissue Inhibitor of Metalloproteinases-1 HF Heart failure DCM Diabetic cardiomyopathy LDH lactate dehydrogenase PPAR peroxisome-proliferator-activated receptor PGC-1 PPAR co-activator-1 GDF-15 growth differentiation factor 15 PK2 Prokineticin 2 PKR1/2 prokineticin receptor1/2 GSK3B Glycogen synthase kinase-3 beta TNF- Tumor Necrosis Factor alpha CRP C-reactive protein DOX doxorubicin IL-6 Interleukin 6 PINK1 phosphatase and tensin homolog (PTEN)induced putative kinase 1 Mfn1/2 Mitofusins1/2 GLP-1 glucagon-like peptide-1 SGLT1 sodium-glucose cotransporter 1 RCT Randomized Controlled Trial References 1 AguilarD.ChanW.BozkurtB.RamasubbuK.DeswalA

Activation of platelet-activating factor receptor-coupled G q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells