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Considering the favorable safety profile of both curcumin and piperine, along with their demonstrated efficacy in preclinical models, CUR-PP holds significant promise for future clinical trials aimed at slowing neurodegeneration, improving cognitive outcomes, and providing neuroprotection across diverse patient populations

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Updates to the checklist included clarifications about stepwise approaches to return to sport, inclusion of the clinical office-based evaluation tool Sport Concussion Office Assessment Tool 6, and additional post-concussion management guidance