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The loading phase of TB-500 builds tissue concentrations of the peptide before tapering to maintenance

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Semin Oncol, 10: 330-341

From the list of 15 proteins involved in metabolism, ROS homeostasis, and apoptosis, only a handful seem to be (1) regulated by reversible S-glutathionylation and (2) display altered S-glutathionylation patterns in various pathologies (Mailloux et al., 2013a)