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While the comproportionation reaction is a well reported redox cycling chemical mechanism, in this instance the triad model does not require the additional comproportionation reaction to accurately replicate the experimental OCR profile, suggesting that the comproportionation reaction is not mechanistically integral to the production of ROS through a quinone-based redox cycle

Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (No

Association between weight reduction achieved with tirzepatide and health-related quality of life in people with overweight or obesity