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Interestingly, this treatment combined with either sirtinol or olaparib enhanced the sensitivity of the cells against FK866 both in mass cultures and tumorspheres, suggesting that these combinations can be used to reduce the toxic effects of NAMPT inhibition during the incorporation of a more effective therapy

Symptoms of a reaction might include a skin rash or hives

Compared to individuals with weak metabolic or transport phenotypes, those with strong phenotypes are more susceptible to inhibition by DME or DT, and the degree of inhibition is greater [126]

Upon activation, NRF2 triggers the expression of hundreds of genes involved in various cellular processes, including antioxidant and xenobiotic responses, cell proliferation and survival, and metabolism, among others 9,27