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Abbreviations AMPK: AMPactivated protein kinase AQP3: Aquaporin-3 AUC: Area under the curve Bax: Bcl-2-associated X protein Bcl-2: Bcell lymphoma 2 CBG: Cytosolic broadspecificity betaglucosidase CHOP: C/EBP homologous protein DART-MS: Direct analysis in real time mass spectrometry DDAs: Diester-diterpenoid alkaloids DDIT4: DNA damage inducible transcript 4 DESI-MSI: Desorption electrospray ionization mass spectrometry imaging EG: Emodin8 O D glucoside EMD: Emodin EVO: Evodiamine EVO-Cys: Evodiamine-cysteine conjugate EVO-Cys-Gly: Evodiamine-cysteinyl-glycine conjugate GLUT2: Glucose transporter 2 GSH: Glutathione HCN: Hydrogen cyanide HIF-1: Hypoxiainducible factor 1 IL-1: Interleukin1beta LPH: Lactasephlorizin hydrolase MAPK: Mitogenactivated protein kinase MDA: Malondialdehyde MDAs: Monoester-diterpenoid alkaloids mTOR: Mammalian target of rapamycin NDAs: Nonesterditerpenoid alkaloids NF-B: Nuclear factor kappalightchainenhancer of activated B cells NLRP3: NODlike receptor family pyrin domain containing 3 OATs: Organic anion transporters PERK: PKRlike ER kinase PGC-1: Peroxisome proliferatoractivated receptor gamma coactivator 1alpha PKC: Protein kinase C PMA: Phorbol 12myristate 13acetate PPAR: Peroxisome proliferatoractivated receptor gamma RIP: Ribosome-inactivating protein ROS: Reactive oxygen species SGLT1: Sodium-glucose linked transporter 1 SOD: Superoxide dismutase TCM: Traditional Chinese Medicine TCMs: Traditional Chinese Medicines TNF: Tumor Necrosis Factor-alpha References Ya-Zhu W, Xiao-Ting W, Shu-Qing T, et al

He is affiliated with several academic and clinical institutions in Taiwan, including National Taiwan University Hospital and Chang Gung University