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Introducing electron-donating groups into hydrazone linkers can accelerate hydrolysis, enabling faster payload release, whereas electron-withdrawing groups can slow cleavage, enhancing plasma stability and reducing off-target release

developed a charge-reversible MCM@CS@PEG-APT (DOX-GFP) nanosystem that minimises off-target effects by pH-sensitive charge transition, enhancing tumour selectivity, reducing systemic toxicity, and ensuring efficient drug delivery in breast cancer therapy [74]

Interestingly, suppressing SCD-1 may improve insulin sensitivity, reduce fat deposits, and increase basal energy expenditure, suggesting its connection to lower SAA consumption and lipid metabolism

Abstract Understanding and treating inflammation has proven a formidable challenge