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Continuous oxidative damage to mtDNA has been linked to aging, inflammation, carcinogenesis, and the development of malignancy [47]

Kleeman CR, Tuttle S, Bassett SH

doi: 10.1016/j.phymed.2024.155347 25 HeidarzadehpilehroodR.PirhoushiaranM.AbdollahzadehR.Binti OsmanM.SakinahM.NordinN.et al

After obtaining thalidomide-based electrophiles, they reacted on-bead with five-amine-containing kinase inhibitors via a direct condensation reaction, in the presence of DIPEA