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Preclinical Evidence: Beyond GH Release Bone Protection A 2001 study investigated whether ipamorelin could counteract glucocorticoid-induced bone loss in rats

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Abbreviations Abs: Absorbance ACP: Acid phosphatase ALP: Alkaline phosphatase ANOVA: One-way analysis of variance AO: Antioxidant ATPases: Adenosine triphosphatase BBM: Brush border membrane BBMV: BBM vesicles bw: Body weight CAT: Catalase CaCl 2 : Calcium chloride DPCs: DNA-protein crosslinks DPPH: 2,2-Diphenyl-1-picrylhydrazyl DTNB: 5,5-Dithibisonitrobenzoic acid EDTA: Ethylenediaminetetraacetic acid FeCl 3 : Ferric chloride FRAP: Ferric reducing antioxidant power F6Pase: Fructose 1,6-bisphosphatase G6Pase: Glucose 6-phosphatase G6PD: Glucose 6-phosphate dehydrogenase GGTase: -Glutamyl transferase GP: Glutathione peroxidase GR: Glutathione reductase GSH: Reduced glutathione GSSG: Oxidized glutathione GST: Glutathione-S-transferase HCl: Hydrochloric acid H and E: Hematoxylin and eosin H 2 O 2 : Hydrogen peroxide HK: Hexokinase KCl: Potassium chloride LAP: Leucine aminopeptidase LDH: Lactate dehydrogenase LD: Lethal dose LMA: Low melting agarose LPO: Lipid peroxidation MDA: Malondialdehyde MDH: Malate dehydrogenase ME: Malic enzyme NaCl: Sodium chloride NAD + : Nicotinamide adenine dinucleotide NADH: Nicotinamide adenine dinucleotide (reduced) NADP + : Nicotinamide adenine dinucleotide phosphate NADPH: Nicotinamide adenine dinucleotide phosphate (reduced) Ni: Nickel NiCl 2 : Nickel chloride PO: Protein oxidation RPMI: Rosewell Park Memorial Institute rpm: Revolutions per minute ROS: Reactive oxygen species O 2 : Superoxide radical OH: Hydroxyl radical SDS: Sodium dodecyl sulphate SH: Sulfhydryl SOD: Superoxide dismutase TNB: 5-Thionitrobenzoate TR: Thioredoxin reductase w/v: Weight/volume C: Degree Celsius %: Percent g: Gram kg: Kilogram l: Microliter ml: Milliliter M: Molar mM: Millimolar mg: Milligram nm: Nanometer mm: Millimeter m: Micrometer h: Hour min: Minute mA: Milliampere V: Volt References Abdelsalam NA, Ramadan AT, El Rakaiby MT, Aziz RK (2020) Toxicomicrobiomics: the human microbiome vs